Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset alzheimer’s disease

HIGHLIGHTS

• who: Francisco Tejedor and collaborators from the Analysis The Bowtie-TopHat-Cufflinks pipeline was used as previously described (Trapnell et al, )Reads were mapped on M. musculus mm, genome and the University of California, Santa Cruz (UCSC) known genes was used as transcriptome index. Cuffmerges were run on all samples. The merged assembly were mapped on the Gencode (release, ) main annotation and all the transcripts which were not described within were removed (antisense genes, unknown transcript) to focus on protein-coding genes. For the quantification (cuffquant) of the abundance, the frag-bias-correct and the multi-read . . .
  

   

  

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