HIGHLIGHTS
- who: Jonas Paulsen from the (UNIVERSITY) have published the research work: Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts, in the Journal: (JOURNAL)
- what: The authors show that TADs associated with LMNA are mainly placed towards the NP whereas interacting TAD pairs without a LMNA-directed peripheral positional constraint are more evenly distributed in the nucleus (Fig 1d, e). The authors show an application of Chrom3D to the study of disease mechanisms using FPLD2 patient-specific positional constraints imposed by a LMNA mutant displaying alterations in its association with the . . .
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