Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin

HIGHLIGHTS

• who: Oliver Ocsenas and Ju00fcri Reimand from the Medical Biophysics, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University have published the paper: Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin, in the Journal: (JOURNAL) of August/10,/2022
• what: This analysis shows that in most cancer types, regional mutagenesis is more strongly associated with chromatin accessibility of primary human cancers rather than normal tissues and cell lines, even when accounting for DNA replication timing in the comparison. This analysis shows that although individual frequently mutated . . .
  

   

  

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