HIGHLIGHTS
- who: Qianqian He from the (UNIVERSITY) have published the Article: Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects, in the Journal: (JOURNAL)
- what: The authors report downstream cell fate consequences and tumorigenic implications of cell populations with mild (cells with and amp;lt; 5 chromosomes lost or gained) and severe aneuploidy ( ≥ 5 chromosomes lost or gained, including polyploidy). The authors propose a model where mildly aneuploid cells in response to lower degree of chromosome mis-segregation continue proliferating, whereas severely aneuploid cells are capable of entering a p53dependent senescence (Fig 8). Although aneuploidy . . .
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