Chromosome 11q loss and mycn amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

HIGHLIGHTS

• who: Kaylee M. Keller from the Sant Joan de Du00e9u Hospital, Spain Essen University Hospital, Germany have published the paper: Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma, in the Journal: (JOURNAL)
• what: Altogether the study demonstrates the potential of using Frontiers in Oncology The authors use the characteristic hemizygous loss of chromosome 11q in NB to explore targetable vulnerabilities that can be used for therapeutic purposes.
• how: The authors used an isogenic 11q deleted NB model system together with high-throughput drug screening to . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.