Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme ttll11

HIGHLIGHTS

• who: Ivan Zadra from the (UNIVERSITY) have published the research work: Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11, in the Journal: (JOURNAL) of 22/Dec/2021
• what: The authors show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is essential to define their dynamics within the range required for error-free chromosome segregation.
• how: Altogether these data showed that elongation of glutamate chains on the spindle MTs but not branching was abrogated in the TTLL11-silenced cells. TTLL11 is essential for chromosome segregation fidelity To . . .
  

   

  

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