Chronic activation of gpr40 does not negatively impact upon brin-bd11 pancreatic β-cell physiology and function

HIGHLIGHTS

  • who: Eloisa Aparecida Vilas-Boas from the Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo (USP), Sao Paulo, SP, Brazil have published the research: Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function, in the Journal: (JOURNAL)
  • what: The authors sought to investigate the impact of chronic GPR40 activation on β-cell viability and function using the GPR40 agonist GW9508. Specifically, the authors focused on ­Ca2+ homeostasis, induction of UPR and changes in intracellular ­H2O2 levels. Interestingly, the authors show that chronic incubation of . . .

     

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