HIGHLIGHTS
- who: Benoît J. Pons from the Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France have published the research work: Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response, in the Journal: (JOURNAL)
- what: The authors show that chronic exposure to CDT in HeLa cells or mouse embryonic fibroblasts promotes a strong type I interferon (IFN) response that depends on the cytoplasmic DNA sensor cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) through the recognition of micronuclei. The authors show . . .
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