Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination

HIGHLIGHTS

• who: Fay A. Guarraci from the Female rats (n=24) and male rats (n=16) were bred from adult Long-Evans rats purchased from Envigo (Indianapolis, IN, USA)All experimental procedures were approved by the Southwestern University IACUC and followed NIH guidelines. Additional adult female and male rats were purchased from Envigo and used as stimulus rats. Stimulus rats were gonadally intact, sexually experienced male and female rats, with female stimulus rats only being used when in behavioral estrus (i.e., estrus phase of the estrous cycle). All rats were group-housed with same-sex cage mates . . .
  

   

  

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