HIGHLIGHTS
SUMMARY
The authors found a training effect on metabolism related to glutathione biosynthesis in both male and female players, whereas an increase in branched chain amino_acids was observed only in male players. The metabolites identified as significantly associated with chronic training in both male and female athletes are related to amino_acid biosynthesis and translation, as evidenced by modulation of the aminoacyl-tRNA biosynthesis pathway. Ornithine is involved in the urea_cycle, and its increase could indicate a rise in the urea_cycle to eliminate ammonia produced by amino_acid degradation during chronic training. In males, but not in . . .
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