Chst15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk

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• who: Yi Chen from the Patients and samples Patients were diagnosed with PMF and ET according to the World Health Organization (WHO) criteria [15]Familial cases were defined when two or more individuals in the same pedigree were affected with MPNs.Blood samples from familial patients (n=6), family members (n=9), patients with sporadic MPN (n=110) and healthy subjects (n=160) were collected after informed written consent was obtainedin accordance with the Declaration of Helsinki. This study was approved by the institutional ethics committee of The Second Xiang-Ya Hospital, Central South University. To detect . . .
  

   

  

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