Cigarette smoke-induced gasdermin d activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on nlrp3

HIGHLIGHTS

  • who: Sarah Huot-Marchand from the Gene Therapy (SR-Tiget), Italy University of Alabama at Birmingham have published the paper: Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3, in the Journal: (JOURNAL)
  • what: The authors focused on matrix metalloproteinase (MMP)-9, a gelatinase produced by alveolar macrophages and neutrophils that degrades extracellular matrix proteins and promotes neutrophil chemotaxis, and MMP-12 an elastase mainly produced by alveolar macrophages that contributes to alveolar damages and their inhibitor tissue inhibitor of matrix metalloproteinase 1 (TIMP-1). Using an antibody . . .

     

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