Circadian clocks, cognition, and alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

HIGHLIGHTS

• who: Kari R. Hoyt from the (UNIVERSITY) have published the paper: Circadian clocks, cognition, and Alzheimeru2019s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics, in the Journal: (JOURNAL)
• what: The work described here, suggest that early in AD-like disease progression there is a disruption of systems-level circadian timing within forebrain circuits that are required for learning and memory, and concordant with this loss of cellular timing, there are marked cognitive deficits (Fig 3).
• how: In this paper the authors used a transgenic approach in which a CaMKII-tTA line was used to . . .
  

   

  

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