HIGHLIGHTS
- who: Lifeng Ding from the Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China have published the article: circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA, in the Journal: (JOURNAL)
- what: In this study, RNA-pulldown assay was performed, and WTAP was identified to bind with circPDE5A.
- how: Chromatin immunoprecipitation assay (ChIP) and dual-luciferase reporter assay were used to identified transcriptional factor which regulated circPDE5A expression. The results showed that only hsa_circ_0002474 derived from PDE5A designated as circPDE5A was . . .
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