Circptn promotes the progression of non-small cell lung cancer through upregulation of e2f2 by sponging mir-432-5p

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SUMMARY

    The functional roles of circPTN and miR-432-5p in NSCLC remain unclear. Considering these aspects, in this study, the authors attempted to unveil the expression pattern and functional role of circPTN and miR-432-5p in NSCLC. 2-ΔΔCt method was adopted for relative gene_expression analysis, with GAPDH and U6 being the endogenous references. The authors reported a high-level expression of circPTN in NSCLC cells and tissues, which is associated with a poor prognosis in NSCLC patients. Silencing circPTN impaired the malignant phenotype of NSCLC cells. Since circPTN and miR-432-5p . . .

     

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