HIGHLIGHTS
- who: Lunhua Liu from the (UNIVERSITY) have published the article: Circulating CD138 enhances disease progression by augmenting autoreactive antibody production in a mouse model of systemic lupus erythematosus, in the Journal: (JOURNAL) of May/10,/2021
- what: The authors reported the augmentation of APRILmediated B-cell survival, differentiation, and ERK trypsin cleavage, and blocking of trypsin led to CD138 retention on TCRβ+CD138- cell membrane (Fig 6).
SUMMARY
Although T-cell receptor β (TCRβ)+CD138+ T_cells typically expand in MRL/Lpr mice as the disease progresses, surprisingly, TCRβ+CD138- cells were the . . .
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