Circulating tumor dna combining with imaging analysis for lesion detection of langerhans cell histiocytosis in children

HIGHLIGHTS

• What: The authors focus on how these two modalities can complement each other to enhance diagnostic accuracy and patient management, and the final goal is to examine the broader role of ctDNA in monitoring the disease. The study was approved by the Ethics Committee, and informed consent was obtained from the parent or legal guardian of each individual participant included in the study. The authors dynamically monitored cfBRAFV600E status at multiple time points during chemotherapy in children with LCH and evaluated the correlation between cfDNA molecular responses and clinical outcomes. The authors propose that cfBRAFV600E progression can . . .
  

   

  

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