Cis-mediated interactions of the sars-cov-2 frameshift rna alter its conformations and affect function

HIGHLIGHTS

• who: Lukas Pekarek and collaborators from the Helmholtz Institute for RNA-based Infection Research (HIRI-HZI), Wuu0308rzburg, Germany and , Medical Faculty have published the Article: Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function, in the Journal: (JOURNAL) of June/15,/2022
• what: The authors show that the canonical PK is the effective structure to stimulate frameshifting, and that both the standard and the threaded PK folds can induce frameshifting . Using locked nucleic_acid (LNA) containing ASOs targeting the SL2 of the pseudoknot the authors show that the authors . . .
  

   

  

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