Ck1α plays a central role in mediating mdm2 control of p53 and e2f-1 protein stability

HIGHLIGHTS

  • who: Anne-Sophie Huart from the (UNIVERSITY) have published the article: CK1u03b1 Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability, in the Journal: (JOURNAL) of November/20,/2009
  • how: The results showed that p53 and MDM2 protein levels were increased after x-ray in the siRNA controls.

SUMMARY

    Most residues that are phosphorylated are targeted by many different kinases in response to various stresses when p53 is activated, although some phosphorylations have been reported to be inhibitory. In unstressed cells, p53 is under the . . .

     

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