Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression

HIGHLIGHTS

  • who: Wataru Shiraishi from the DepartmentKyushu University have published the research: Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression, in the Journal: Scientific Reports Scientific Reports of 23/01/2021
  • how: The results are compatible with previous results showing C ­ D68+ macrophages infiltrated the ventral roots of m ­ SOD1G93A mice at 60 days of ­age22. The results showed that ­CCR2+ cell | 1116438 | 11 Vol.(0123456789)

SUMMARY

    Conversely, the sciatic nerves of SOD1G93A/CCR2RFP/WT/CX3CR1GFP/WT mice showed a marked increase of ­CX3CR1 . . .

     

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