HIGHLIGHTS
SUMMARY
By being connected with these conditions, NAFLD, defined as the presence of >5% steatosis in the liver, can be identified as a hepatic expression of metabolic syndrome (MetS). The "first hit" involves fatty_acids (FA) accumulation in the hepatocytes increasing the vulnerability of the liver to many factors that constitute the "second hit" and promote hepatic injury, inflammation and fibrosis. Due to its crucial role as a regulator in hepatocytes and stellate cells, PNPLA3 hydrolyzes triglycerides and catalyzes the transfer of the polyunsatured fatty_acids (PUFA) from di- and tri-acyglycerols to phosphocholines. In a metabolic . . .
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