HIGHLIGHTS
- who: Tomofumi Uto from the of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan have published the article: Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 12/04/2016
- what: The authors show by characterizing Clec4A4-deficient mice that Clec4A4 acts as a unique regulatory CLR in the context of TLR-mediated activation of CD8a cDCs. The authors show that retroviral transfection of Clec4A4 into cDCs impairs TLR-mediated cytokine production, possibly through . . .
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