HIGHLIGHTS
SUMMARY
Hypoactive sexual desire disorder (HSDD) is characterized by a persistent or recurrent deficiency of sexual fantasies and desire for sexual activity, resulting in marked distress and interpersonal difficulties. Acquired HSDD develops in an individual who previously had no problems with sexual desire, while generalized HSDD occurs regardless of the type of stimulation, situation, or partner. A novel MC4R agonist (MC4Ra) has been shown to enhance sexual desire in women with HSDD and has been licensed by the FDA for clinical use in premenopausal women with HSDD. To determine the mechanism by which MC4R agonists . . .
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