HIGHLIGHTS
- who: Kristine Misund from the (UNIVERSITY) have published the research work: Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence, in the Journal: (JOURNAL) of 28/05/2022
- what: The study provides proof of principle that melphalan can have a mutagenic effect on myeloma cells irrespective of dose-intensity.
- how: The data showed that the phenotypic transformation is more pronounced at end-stage disease.
SUMMARY
Even though specific mutations in drug_targets are rarely identified, biallelic events in tumor suppressor genes and gain1q have shown . . .
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