Clonality assessment and detection of clonal diversity in classic hodgkin lymphoma by next-generation sequencing of immunoglobulin gene rearrangements

HIGHLIGHTS

• who: Diede A. G. Bladel from the This study was performed with , lymph node biopsies of patients diagnosed with cHL according to the , revised, th edition of the World Health Organization classification25, for which both FFPE and FF tissue material was available, (Table , and Supplementary Table, )IG-NGS was analyzed on all , cases, both FFPE and FF, while BIOMED-2/EuroClonality analysis could only be performed on , FFPE cases, due to limited DNA yield for case, but included all , FF cases. For clone definition and identification, available IG-NGS clonality data of , reactive lymphoproliferative samples was analyzed . . .
  

   

  

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