Clonesig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data

HIGHLIGHTS

• who: Judith Abécassis from the Research University have published the Article: CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose CloneSig, a method to jointly infer ITH and estimate mutational processes active in different clones from bulk genome sequencing data of a tumor sample. The authors evaluate TrackSig18, that reconstructs signature activity trajectory along tumor evolution by binning mutations in groups of 100 with decreasing CCFs, and for each group performs signature activity deconvolution using an . . .
  

   

  

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