Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for r1128, a non-steroidal estrogen receptor antagonist

HIGHLIGHTS

• who: Thomas Marti from the (UNIVERSITY) have published the Article: Cloning, Nucleotide Sequence, and Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-steroidal Estrogen Receptor Antagonist, in the Journal: (JOURNAL) of July/28,/2000
• what: Specifically, the authors propose that the R1128 synthase recruits four subunits from the endogenous fatty_acid synthase during the biosynthesis of this family of pharmacologically significant natural products.
• future: Together with an ACP (encoded by either zhuG or zhuN) and a malonyl-CoAACP malonyltransferase (MAT) which is recruited from the endogenous fatty_acid synthase the KS-CLF . . .
  

   

  

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