Close relatives of mers-cov in bats use ace2 as their functional receptors

HIGHLIGHTS

• who: Qing Xiong from the Bat CoV/Hsavii/ Italy have published the Article: Close relatives of MERS-CoV in bats use ACE2 as their functional receptors, in the Journal: (JOURNAL) of 24/01/2022
• what: The authors show that close relatives of MERS-CoV, such as NeoCoV and PDF-2180, engage bat ACE2 for efficient cellular entry.
• how: Although the two viruses could not use hACE2 efficiently the study also reveals that single-residue substitution increasing local hydrophobicity around NeoCoV site 510 could enhance their affinity for hACE2 and enable them to enter . . .
  

   

  

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