HIGHLIGHTS
- who: Benjamin G. Trist from the Faculty of Medicine and Health, The University of Sydney, Sydney, NSW , have published the article: Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration, in the Journal: (JOURNAL)
- what: The authors demonstrate close spatial relationships between disordered SOD1, pathological TDP-43 and p62 pathologies within these neurons, suggesting interactions between these proteins modulate the formation of their respective proteinopathies. Considering that disruption of protein transport along the ER-golgi axis constitutes an early event in SOD1-fALS pathogenesis , preceding protein aggregation . . .
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