Co-ultramicronized palmitoylethanolamide/luteolin restores oligodendrocyte homeostasis via peroxisome proliferator-activated receptor- in an in vitro model of alzheimer’s disease

HIGHLIGHTS

SUMMARY

Very recent in_vitro and in_vivo evidence reported the effect of Aβ in stimulating the maturation of OPCs and promoting the expression of the myelin basic protein (MBP). Molecules acting as agonists of these receptors have demonstrated anti-inflammatory and neuroprotective properties in different in_vitro and in_vivo models of CNS diseases. Co-ultra PEALut significantly reduced the development of encephalomyelitis in an in_vivo experimental model of MS. Treatments with human Aβ1-42 1 µm inorthe presence absence of with human fibrillary Aβ1-42 1fibrillary μm in the presence absence ofor coOlig2+ cell counts . . .

 



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