Co2 signaling mediates neurovascular coupling in the cerebral cortex

HIGHLIGHTS

• who: Patrick S. Hosford from the University College have published the paper: CO2 signaling mediates neurovascular coupling in the cerebral cortex, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Supporting dynamic neuronal metabolic needs by maintaining an uninterrupted delivery of oxygen and glucose is thought to be the main purpose of the neurovascular coupling response. The authors show in experimental animal models (rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of brain CO2sensitive vasodilatory mechanism with surplus of exogenous CO2 or disruption of . . .
  

   

  

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