Coal miners and lung cancer: can mortality studies offer a perspective on rat inhalation studies of poorly soluble low toxicity particles?

HIGHLIGHTS

SUMMARY

    Despite these mathematical analyses that indicate that coal miners do not develop "lung overload" as physiologically defined, the term "lung overload" is often used colloquially in regulatory and other settings to describe the extent of dust retention in coal miners in comparison to other occupational groups. As a result, it seems wise for the purpose of this review to raise the question that If coal miners do experience "lung overload" could studies of risk of lung cancer among coal miners provide a perspective on the human significance of rat inhalation studies of poorly soluble . . .

     

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