Coarse-grained simulations suggest potential competing roles of phosphoinositides and amphipathic helix structures in membrane curvature sensing of the ap180 n ‑ terminal homology domain

HIGHLIGHTS

• who: Alexis Belessiotis-Richards et al. from the Alexis Belessiotis-Richards, Department of Materials, Imperial College London, London , AZ, UK. have published the Article: Coarse-Grained Simulations Suggest Potential Competing Roles of Phosphoinositides and Amphipathic Helix Structures in Membrane Curvature Sensing of the AP180 N ‑ Terminal Homology Domain, in the Journal: (JOURNAL) of January/12,/2022
• what: We have studied the membrane curvature activity of the ANTH domain with three different helix structures under PC-only and PIP2-containing membrane conditions.
• how: The authors investigated how PIP2 affects the ANTH domain's curvaturesensing . . .
  

   

  

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