Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant hiv-1 reverse transcriptase, preserving its th2-polarity

HIGHLIGHTS

• who: A. A. Latanova from the (UNIVERSITY) have published the research work: Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity, in the Journal: (JOURNAL) of 10/Nov/2017
• what: The authors aimed to enhance the Th1 arm of the immune_response against HIV-1 RT, in-going into the prototype multigene vaccine against drug-resistant HIV14 (see15 for review). By using c-di-GMP, the authors intended to stimulate the detection of double-stranded DNA by cytosolic DNA sensors . . .
  

   

  

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