HIGHLIGHTS
SUMMARY
Among cognitive functions known to worsen during brain aging, the most affected cognitive ability is episodic memory, declining early over time and displaying various severity extent. ERGO-rich He2 primordium was administered to mice starting from 15 months of age, during the adulthood life phase, until 23 months of age, corresponding to the senescence period. Memory through a multisynaptic loop, and less vulnerable to aging process, could Hippocampus is one of the most vulnerable organs of the CNS to neurodegeneration be differently exploited by young and aged mice. For instance, high levels of IL6 . . .
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