HIGHLIGHTS
- who: Alejandro R. Roda et al. from the The triple-transgenic mouse model of Alzheimer's disease (3xTg-AD) was engineered at the University of California, Irvine, by introducing APPSwe and MAPTP L transgenes into a PS M V homozygous knock-in single-cell embryo [26]Female mice were selected because they conserve the phenotype as originally described [40] and exhibit greater Aβ burden and larger behavioral deficits than age-matched male mice [41]. Animals used in the present work belong to the, xTg-AD colony, and the corresponding non-transgenic (NTg) mice (B SF2), stablished by . . .
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