HIGHLIGHTS
SUMMARY
Collected information on 3.4 million blood donors from the Shaanxi Blood Donor Database during 1998-2018. Reducing iron overload through regular blood donation may prevent cancer, hemochromatosis, and liver diseases, but iron depletion and iron deficiency with anemia are common among frequent blood donors. We, therefore, established a large natural population cohort consisting of an equal number of both blood donors and non-blood donors of comparable demographics to assess the impacts of blood donation on donors` subsequent disease burden following blood donation. Most of these studies were longitudinal studies or cohort studies . . .
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