HIGHLIGHTS
- who: Yirui Guo from the (UNIVERSITY) have published the paper: Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization*, in the Journal: (JOURNAL) of March/20,/2015
- how: To test this hypothesis a mutagenesis study with different combinations of charged residues at the ARNT Glu-362 and TACC3 Asp-622 positions was conducted to examine the binding affinity alteration. This result is well accommodated with a ternary structure model where most of the highly affected residues (spheres) are clustered in the vicinity of ARNT PAS-B S451C-CMTSL spin label . . .
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