Cold exposure induces intestinal barrier damage and endoplasmic reticulum stress in the colon via the sirt1/nrf2 signaling pathway

HIGHLIGHTS

  • who: SIRT and colleagues from the Medicine, Heilongjiang Bayi Agricultural University, Daqing, China have published the Article: Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway, in the Journal: (JOURNAL)
  • what: The authors demonstrated that chronic cold exposure activated ER stress, which mediates apoptosis, inflammation and oxidative stress in the colon via the SIRT1/Nrf2 signaling pathway.
  • how: The following transfection conditions were used 2.5 u03bcg shRNA plasmid and 4 u03bcL Lipo8000 transfection reagent were added to six-well plates and samples . . .

     

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