HIGHLIGHTS
SUMMARY
The genomic profiling of these patients demonstrated features classically associated with increased responses to CPIs, including a high programmed death ligand 1 (PD-L1) expression, high tumor mutational burden (TMB), high microsatellite instability (MSI-high), and deficient mismatch repair genes (dMMRs). The concept of using stereotactic body radiation therapy (SBRT) to boost responses to CPIs in solid tumors is being investigated, although no data are available in pSCC. The routine use of radiation therapy (RT) is controversial in pSCC, and treatment responses may differ between HPV-positive and HPV-negative cases. A retrospective study . . .
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