Combination of polythyleneimine regulating autophagy prodrug and mdr1 sirna for tumor multidrug resistance

HIGHLIGHTS

• who: Changduo Wang from the (UNIVERSITY) have published the Article: Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance, in the Journal: (JOURNAL)
• what: To fight overall MDR a novel targeted gene/drug co-deliver nano system is developed which can suppress the drug efflux pumps and modulate to overcoming both pump and non-pump resistance.
• how: To determine the optimal weight ratio (PP/siRNA) for siRNA delivery the authors used agarose gel electrophoresis to evaluate the siRNA encapsulation of PP (Fig 2B). To confirm the drug loading contents . . .
  

   

  

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