HIGHLIGHTS
- who: Hannah R. Warren and colleagues from the DepartmentUniversity of have published the article: Combinatorial approaches for mitigating resistance to KRAS-targeted therapies, in the Journal: (JOURNAL) of 23/09/2022
- what: Unlike the studies described above, the authors wanted to compare and contrast resistance mechanisms amongst different classes of Ras pathway inhibitors.
- future: Work is needed to explore this.
SUMMARY
Instead, the authors identified triple inhibitor combinations that resulted in more durable responses to KRAS inhibitors and that may benefit from further pre-clinical evaluation. Anticipating that KRASG12C . . .
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