Combined dopamine and grape seed extract-loaded solid lipid nanoparticles: nasal mucosa permeation, and uptake by olfactory ensheathing cells and neuronal sh-sy5y cells “2279

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SUMMARY

    The obtained SLNs combining DA and GSE were herein evaluated for 3 of 19 their physicochemical properties, cytobiocompatibility and cellular uptake and were also compared with DA-loaded SLNs physically adsorbing GSE previously described by the authors. Tested samples included plain SLNs, DA-co-GSE SLNs and GSE-ads-DA-SLNs. DSC calorimetric runs were carried out for bulk materials, freeze-dried DA-co-GSE SLNs and freeze-dried GSE-ads-DA-SLNs using a Mettler Toledo DSC 822e STARe 202 system combined with a DSC MettlerSTARe software v.2 (Mettler Toledo, Milan, Italy . . .

     

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