HIGHLIGHTS
- who: Baskar Ramdas et al. from the DepartmentIndiana University have published the Article: Combined heterozygosity of FLT3ITD TET2 and DNMT3A results in aggressive leukemia, in the Journal: (JOURNAL)
- what: The authors have analyzed and compared the genetic, phenotypic, and transcriptomic features of AML driven by a combination of FLT3ITD TET2, FLT3ITD DNMT3A, or FLT3ITD TET2 DNMT3A, utilizing AML models, patient cells, and transcriptomic data derived from both mice and humans. In the current study, the ssGSEA analysis revealed greater coagulation activity, as well as elevated intrinsic pathway and CXCR chemokine binding in TFD compared with . . .
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