Commd10 is critical for kupffer cell survival and controls ly6chi monocyte differentiation and inflammation in the injured liver

HIGHLIGHTS

  • who: Keren Cohen from the Center for DigestiveAviv University Cedars-Sinai Medical Center, Los Angeles, CA, USA have published the research work: COMMD10 is critical for Kupffer cell survival and controls Ly6Chi monocyte differentiation and inflammation in the injured liver, in the Journal: (JOURNAL) of November/16,/2021
  • what: The authors show that copper metabolism MURR1 domain (COMMD)10-deficient KCs adopt liver-specific identity. Based on the NeuMo and DCMo marker genes described in these two studies the authors show here that COMMD10 deficiency in Ly6Chi monocyte generates a clear bias toward NeuMos.
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