HIGHLIGHTS
- who: E. Sally Ward from the DepartmentUniversity of Station, TX, USA have published the paper: Commentary: "There's been a flaw in our thinking", in the Journal: (JOURNAL)
SUMMARY
The negligible binding of IgG to FcRn at pH 7-7.4 supports the concept that fluid-phase, pinocytic uptake is the primary mediator of ligand entry into cells exposed to this pH range. In the absence of information concerning the pH dependence of FcRn-IgG interactions around 50 years ago, it was not possible to postulate the mechanism of IgG uptake into cells . . .
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