HIGHLIGHTS
SUMMARY
While transitioning from the compensated to the decompensated state, RV cardiomyocytes experience a metabolic shift including: reduced oxidative_phosphorylation and beta-oxidation of fatty_acids; pyruvate to lactate conversion through aerobic glycolysis (Warburg effect) and its utilization; and_(3) increased utilization of amino_acids especially glutamine (glutaminolysis) in the TCA cycle. The main fuels include fatty_acids, lactate, ketones, glucose, pyruvate, and amino_acids. Only the critical metabolic pathways that are typically associated with cardiomyocyte hypertrophy and contractile function such as glutathione metabolism, aspartate and glutamate metabolism, glycolysis, oxidative_phosphorylation, fatty_acid metabolism, inositol metabolism and TCA (citric acid) cycle are . . .
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