HIGHLIGHTS
SUMMARY
Even more, promising data are available using exosomal miRNAs from saliva for differentiation of patients with oral cancer from healthy subjects (Langevin et_al, 2017; Gai et_al, 2018; He et_al, 2020). To explore the combinatorial potential of exosomes derived from both plasma and saliva, this study systematically compared the exosomal miRNA profiles between plasma and saliva of HNSCC patients and healthy subjects. Dysregulation of miRNA signaling is involved in the tumorigenesis of many cancers, including HNSCC. miRNAs are effectively and selectively packed into exosomes (Valadi et_al, 2007; Groot and Lee, 2020), and their specific genetic . . .
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