HIGHLIGHTS
SUMMARY
MCPyV is part of the human skin microbiome, and it has been detected in up to 80% of MCC samples, as well as in other non-melanoma skin tumors. MCPyV-specific T_cell responses are detected both locally and systemically in patients with MCC, but the frequent expression of PD-L1 by cancer cells inactivates their effects by inducing T_cell exhaustion. In all five head MCC biopsies, four of them resulted MCPyV positive samples, while 2/3 upper limbs` samples were MCPyV-positive tumors. MCPyV was detected in 55% of partially UV-protected site tumors . . .
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