Comparison of the blood-brain barrier transport and vulnerability to p-glycoprotein-mediated drug-drug interaction of domperidone versus metoclopramide assessed using in vitro assay and pet imaging

HIGHLIGHTS

• who: Louise Breuil et al. from the Laboratoire d`Imagerie Biomu00e9dicale Multimodale (BIOMAPS), Universitu00e9 Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Fru00e9du00e9ric Joliot, place du Gu00e9nu00e9ral Leclerc, Orsay, France have published the research: Comparison of the Blood-Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug-Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging, in the Journal: Pharmaceutics 2022, 14, 1658. of /2022/
• what: This study assesses the P-gp substrate properties of domperidone in_vitro in transfected cells expressing the human P-gp.
• how: The in_vitro . . .
  

   

  

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